帕尔沃病毒B19反弹反弹
Stefania Ranno1, Cristina Russo1, Luna Colagrossi1
1Microbiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Journal of medical virology
|May 3, 2025
概括
人类帕沃病毒B19 (B19V) 疫情正在增加,在2024年观察到的感染数量显著增加. 这导致了严重的后果,包括住院和死亡,特别是儿童和孕妇.
科学领域:
- 病毒学 病毒学
- 儿童传染病 儿童传染病
- 流行病学 流行病学
背景情况:
- 人类帕沃病毒B19 (B19V) 引起了一系列疾病,从无症状到危及生命的疾病.
- 疫情发生周期性,最近的国际警报促使本次调查.
- 了解B19V循环对于在疫情期间管理儿科健康至关重要.
研究的目的:
- 分析B19V在第三级儿科医院的循环和临床影响.
- 评估从2018年到2024年的B19V阳性率和临床结果.
- 调查B19V在孕妇中的患病率及其对胎儿结果的影响.
主要方法:
- 追溯分析了9695个血液样本,11个羊水和10827个血清.
- 通过分子和血清学检测直接和间接检测B19V.
- 在一组阳性样本上进行B19V亚型分析.
主要成果:
- 与2018年 (9.8%) 和2023年 (0.8%) 相比,B19V年阳性率在2024年 (32.8%) 激增.
- 在2024年,314名患者的检测结果呈阳性;65%患有初级感染,73.5%住院,11.3%需要接受ICU治疗.
- 严重的结局包括心肌炎,心血管,神经和胃肠道病理,有两例儿科死亡;四种羊水检测呈阳性.
结论:
- 在2024年观察到B19V循环的显著增加,导致严重的临床结果和住院治疗.
- B19V感染影响了患有并发症和没有并发症的儿童,以及孕妇,对未出生的婴儿构成风险.
- 仅检测到B19V亚型1A,具有较低的内基因型多样性,表明存在主导的循环菌株.
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