抗生素诱导的微生物失调症在基于活动的厌食症模型中恶化了结果
Karlijn L Kooij1,2, Nadia Andrea Andreani3,4, Lara Keller5
1UMC Brain Center, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
The International journal of eating disorders
|May 3, 2025
概括
在神经性厌食症 (AN) 的老鼠模型中,便微生物群移植 (FMT) 表明,肠道细菌的存在,而不是AN特定的细菌,改善了结果. 这表明肠道微生物组会影响类似AN的行为.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 神经性厌食症 (AN) 是一种与肠道失调相关的精神疾病.
- 肠道微生物群在AN病变发生中的作用正在调查中.
- 基于活动的厌食症 (ABA) 是一种用于研究AN的老鼠模型.
研究的目的:
- 通过便微生物种移植 (FMT) 在ABA大鼠模型中研究与AN相关的肠道微生物群对疾病相关结果的影响.
- 为了确定AN患者的肠道微生物群与健康对照人群相比是否对AN类表型产生差异影响.
主要方法:
- 威斯塔大鼠接受了抗生素治疗,以耗尽肠道微生物群,然后用来自AN患者或健康对照的样本进行FMT.
- 然后,大鼠被暴露在ABA模型 (轮接入,限制养) 中7天.
- 监测了体重,体温,食物摄入量,车轮活动和微生物组合.
主要成果:
- 抗生素治疗成功地耗尽了肠道微生物群;FMT重新建立了类似于捐赠者的微生物群.
- 仅服用抗生素的组在ABA期间表现出降低的生存率,体重和体温.
- 在ABA模型中,FMT与来自AN患者和健康对照者的微生物群改善了结果.
结论:
- 该研究没有发现证据表明与AN相关的微生物群通过部分移植对厌食症类似的表型作出差异性贡献.
- 肠道微生物组的存在,无论其来源 (AN患者或健康对照),都会对ABA大鼠模型的结果产生积极影响.
- 肠道微生物群在调节ABA模型中观察到的行为和生理结果方面发挥着重要作用.
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