卡切西亚是肝硬化患者死亡率的独立预测因子
Takao Miwa1, Goki Suda2, Ryosuke Tateishi3
1Department of Gastroenterology/Internal Medicine, Graduate School of Medicine, Gifu University, Gifu, Japan.
概括
肝硬化患者的卡赫西亚与肝功能低下和死亡风险增加有关. 早期识别缓解症可以帮助预测这些个体的生存结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
- 临床营养学 临床营养学
背景情况:
- 卡赫西亚是一种在晚期疾病中常见的衰弱性消耗综合征.
- 肝硬化是一种严重的肝病,常常伴有复杂的系统性并发症.
- 了解肝硬化中的缓解症对于患者的管理和预后至关重要.
研究的目的:
- 在肝硬化患者中识别与卡赫克西亚相关的因素.
- 评估卡赫克西亚对肝硬化患者生存率的影响.
主要方法:
- 一个多中心的回顾性队列研究,涉及723名肝硬化患者在日本.
- 卡切西亚的诊断遵循了亚洲卡切西亚工作组的标准.
- 后勤和考克斯比例危险回归模型被用于分析.
主要成果:
- 28%的患者患有白血病,患病率随着肝功能障碍的严重程度而增加 (Child-Pugh类A,B,C).
- 年龄和肝功能指数 (Child-Pugh得分) 与缓冲症有关.
- 在肝硬化患者中,卡切西亚独立预测死亡率增加 (aHR,1.62;95% CI,1.24-2.12).
结论:
- 卡赫西亚与肝硬化中肝功能受损有显著的关联.
- 甲状腺硬化作为一个独立的预后指标,用于肝硬化患者的生存.
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