研究MTHFR (C677T和A1298C) 基因多态性在怀孕期间葡萄糖不耐症的条件下
Bunga Papa Kusuma1, D Lakshmi Lalitha2, Nagarjuna Sivaraj1
1Department of Research and Development, Great Eastern Medical School and Hospital, Srikakulam, Andhra Pradesh, India.
概括
血小板数升高和MTHFR基因变异 (C677T和A1298C) 与妊娠糖尿病 (GDM) 的风险增加有关. 妊娠年龄也在GDM发育中起作用.
科学领域:
- 产科和妇科 产科和妇科
- 遗传学 遗传学 是一个
- 血液学 血液学 血液学
背景情况:
- 孕期糖尿病 (GDM) 影响全球约15.1%的怀孕.
- 在怀孕期间,GDM的特点是葡萄糖不耐受.
- 这项研究调查了与GDM相关的血液学参数和MTHFR基因多态性.
研究的目的:
- 为了确定血液学参数升高与妊娠糖尿病的MTHFR基因多态 (C677T和A1298C) 之间的关联.
- 探索妊娠年龄在GDM风险中的作用.
- 为影响GDM的遗传和血液学因素提供新的见解.
主要方法:
- 一项涉及304名孕妇的病例控制研究 (152名GDM,152名对照).
- 聚合酶链反应-限制片段长度多态 (PCR-RFLP) 用于识别MTHFR基因多态 (C677T和A1298C).
- 分析了血液学参数,包括血小板计数.
主要成果:
- 在GDM风险和妊娠年龄和血小板计数之间发现了显著的关联.
- MTHFR A1298C多态性显示出与GDM风险的显著关联 (p=0.034).
- MTHFR C677T多态性也显示出与GDM风险的显著关联 (p=0.008).
结论:
- 血小板数升高和MTHFR基因多态性 (C677T和A1298C) 是发展GDM的危险因素.
- 妊娠年龄也是GDM发展的一个重要因素.
- 这些发现突显了在安得拉邦地区GDM病原体中遗传和血液学因素的相互作用.
相关概念视频
01:27Glucose Transporters
22.2K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
22.2K
01:20Pathophysiology of Diabetes
805
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
805
01:22Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
01:19Overview of Carbohydrate Metabolism
525
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
525