在全身疗法后恶性肝癌的病理变化
Shinya Kuwabara1, Yugo Kinoshita1, Yuichi Koshiyama1
1Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan.
概括
瘤病理在治疗期间可能发生变化. 对于肝癌患者,在初始治疗肝脏内胆管癌 (ICC) 或肝细胞癌 (HCC) 后,病情进展可能需要重新做活检.
科学领域:
- 在瘤学瘤学.
- 肝病学 肝病学是一种肝病学.
- 癌症生物学 癌症生物学
背景情况:
- 恶性瘤的全身治疗通常依赖于最初的病理诊断.
- 患有渐进性疾病 (PD) 的患者通常会在没有重新活检的情况下接受同一种瘤类型的后续治疗.
- 瘤异质性和演变可以在治疗期间发生,可能改变癌症病理学.
研究的目的:
- 报告恶性肝脏瘤的病例,记录了病理变化.
- 强调在治疗初始反应后,在疾病进展的情况下,可能需要重新活检.
- 讨论瘤病理学变化对治疗策略的影响.
主要方法:
- 一个患有恶性肝脏瘤的病人的病例报告.
- 对治疗史的审查,包括肝脏内胆管癌 (ICC) 的全身疗法.
- 瘤反应,进展性疾病 (PD) 和肝细胞癌 (HCC) 后续治疗的记录.
主要成果:
- 一名最初被诊断为肝脏内胆管癌 (ICC) 的患者在接受ICC导向治疗后,在部分反应和PD后,表现为肝细胞癌 (HCC) 的病理转变.
- 患者在针对HCC的治疗方案中实现了稳定的疾病,在ICC治疗方案的进展后.
- 这种转变表明,瘤病理可以在全身治疗压力下演变.
结论:
- 恶性肝脏瘤病理学可以在全身治疗期间转变.
- 在初始反应后患有PD的患者可能需要通过再活检重新确认瘤病理.
- 根据最新的病理发现调整治疗可能会改善肝癌的结果.
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