消化酶的预测值在患有反流引起的慢性咳的患者中
Jerome R Lechien1,2,3,4, Nathalie De Vos5,6,7, Sven Saussez3,8
1Department of Surgery, UMONS Research Institute for Health Sciences and Technology, Faculty of Medicine, University of Mons (UMons), Mons, Belgium.
概括
与喉回流疾病相关的慢性咳 (LPRD-CC) 患者的症状严重程度更大. 唾液弹性酶和胆盐可以预测LPRD-CC的临床结果,有助于诊断和管理.
科学领域:
- 胃肠病学 胃肠病学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 肺部病理学 肺部病理学
背景情况:
- 慢性咳是一种常见的症状,具有多因素的原因.
- 喉回流性疾病 (LPRD) 越来越被认为是慢性咳的重要原因.
- 需要客观的生物标志物来诊断和管理与LPRD相关的慢性咳 (LPRD-CC).
研究的目的:
- 在LPRD-CC.患者中调查唾液消化酶和胆盐的存在和临床价值.
- 为了确定唾液标记能否预测LPRD-CC症状的严重程度.
主要方法:
- 来自两个欧洲医院的104名LPRD患者的前性受控研究.
- 唾液样本分析了弹性酶,素,素,胆固醇和胆汁酸.
- 患者使用反流症状评分 (RSS),生活质量评分 (QoL-RSS) 和反流症状评分 (RSA) 进行评估,并对LPRD-CC和非CC组进行比较.
主要成果:
- 与没有慢性咳的患者相比,患有LPRD-CC的患者表现出更高的症状严重程度 (RSS,RSA).
- 唾液弹性酶与慢性咳的存在和RSS中度相关.
- 在慢性咳组中,唾液胆盐与RSS-QoL有很强的相关性,唾液pH与食道酸暴露有负相关性.
结论:
- 患有慢性咳的LPRD患者会出现更严重的症状.
- 唾液弹性酶和胆盐显示出作为LPRD-CC.临床发现的预测因素的潜力.
- 这些唾液标记物可能有助于诊断和管理LPRD-CC.
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