认知衰退中的肥胖悖论:BMI动态和APOE基因型在各种认知状态上的影响
Weijie Zhai1,2, Guimei Zhang1,2, Chunxiao Wei1,2
1Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Diabetes, obesity & metabolism
|May 3, 2025
概括
体重不足会增加认知能力下降的风险,而超重或肥胖可能会有保护作用. 体重指数 (BMI) 变化和APOE基因型显著影响认知健康.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 身体质量指数 (BMI) 是代谢健康的关键指标.
- 认知能力下降是老年人群日益关注的一个问题.
- 体重指数对认知功能的影响,特别是与痴呆风险有关的影响,需要进一步研究.
研究的目的:
- 调查身体质量指数 (BMI) 和认知衰退之间的关联.
- 检查BMI变化对认知状态的影响.
- 探索APOE基因型在BMI-认知衰退关系中的调节作用.
主要方法:
- 来自国家阿尔茨海默氏症协调中心 (NACC) 的23,255名个体的分析.
- 使用多变量后勤和考克斯回归模型.
- 进行了以APOE基因型相互作用为重点的子组分析.
主要成果:
- 体重不足的人患轻度认知障碍 (MCI) 和痴呆症的风险明显更高.
- 超重或肥胖与现有认知障碍的个体认知能力下降的风险较低有关,但在正常认知的人中并非如此.
- 年度BMI波动大于5%增加了痴呆风险,而稳定的BMI与较低的风险有关.
- APOE基因型似乎影响了BMI,BMI变异性和认知衰退之间的关系.
结论:
- 研究结果支持"肥胖悖论"在认知健康的背景下.
- APOE基因型在调节BMI对认知衰退的影响方面发挥着至关重要的作用.
- 保持稳定的BMI可能对保持认知功能很重要.
相关概念视频
Obesity
401
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
401
Human Genetics
542
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
542
Bulimia Nervosa
55
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
55
Cognitive Development During Adulthood
66
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
66
Binge Eating Disorders
53
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
53
Alzheimer's Disease: Overview
451
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
451


