根据肝癌患者诊断后酒精消费变化的死亡风险
Thi Tra Bui1, Eunjung Park1, Hee-Yeon Kang1
1Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea.
概括
诊断后的酒精消费增加了男性的肝癌死亡风险,戒酒提高了生存率. 戒酒有利于预后,即使是晚期重度饮酒者.
科学领域:
- 在瘤学瘤学.
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 过度饮酒是肝癌的已知原因之一.
- 诊断后酒精摄入量的变化对肝癌患者存活时间的影响尚未得到充分了解.
研究的目的:
- 评估肝癌诊断后饮酒量变化与幸存者死亡风险之间的关联.
- 为了比较诊断前与诊断后饮酒行为对生存结果的影响.
主要方法:
- 从韩国国家医疗保险服务数据库中利用了2002-2017年间诊断的16637名肝癌患者的数据.
- 诊断前后评估酒精消费水平,使用Cox比例危险模型分析与死亡风险的关联.
主要成果:
- 诊断后的饮酒,无论诊断前的水平如何,与与持续不饮酒者相比,男性的全因死亡风险增加了25%-67%.
- 在诊断后过渡到重度饮酒的男性中观察到显著的死亡率增加.
- 诊断后戒酒显著降低了男性的死亡风险,包括患有晚期肝癌的重饮者. 在女性中没有发现任何显著的关联.
结论:
- 肝癌诊断后的酒精消费与死亡风险增加有关,特别是在男性中.
- 诊断后戒酒对肝癌患者的生存有显著的益处,不管他们以前的饮酒习惯或癌症阶段如何.
- 研究结果强调了诊断后改变生活方式的重要性,以改善肝癌患者的治疗结果.
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