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从贝到生物陶根管密封器:制造及其物理和生物特性

Chanathip Chatphatthanasiri¹, Thanakorn Wasanapiarnpong², Theerapat Chanamuangkon³

¹Department of Operative Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.

International dental journal

|May 3, 2025

概括

新开发的生物陶根管密封器是用贝制成的,其物理和生物特性与商业密封器相似. 这项研究突出了它们在内牙科临床应用的潜力.

科学领域:

生物材料科学生物材料科学
材料工程材料工程材料工程
牙科材料牙科材料

背景情况:

贝是食品工业的废物,具有生物医学应用的潜力.
从可持续来源开发新的生物陶材料对牙科行业至关重要.

研究的目的:

合成和描述一种由贝 (NDBS) 制成的新型生物陶密封剂.
评估新开发的生物陶密封剂 (NDBS) 的物理和生物特性.

主要方法:

合成和分析了来自贝的三酸盐 (C-C3S).
准备了NDBS,并使用XRD,FTIR,SEM和ISO 6876标准评估了其化学成分,表面形态和物理特性.
生物评估包括细胞毒性,增殖试验 (MTT) 和人类牙周带细胞的基因表达分析 (RT-qPCR).

主要成果:

合成的C-C3S含有55%的三酸,颗粒大小为5.32微米.
NDBS表现出可接受的流动性,定时间,薄膜厚度和辐射透明度,pH值超过7和可比的释放对照.
MTT测试显示,在稀释后,细胞活力得到改善,RT-qPCR表明,促进炎症的基因表达减少,性酸酶基因表达上调.

结论:

贝可以用来制造一种新的生物陶密封剂 (NDBS),其物理和生物特性与iRoot SP.等现有商业密封剂相比较.
该研究表明,NDBS作为根管密封应用的可行替代品具有重大潜力.

关键词:

生物陶是一种生物陶.的贝的贝细胞毒性测试细胞毒性测试物理性质测试试验物理性质测试试验根管道密封剂是一种根管道密封剂.

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