长期COVID中持续的神经认知缺陷:在轻度感染后,有结构变化和网络异常的证据
Bedia Samanci1, Ulaş Ay2, Haşim Gezegen1
1Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
概括
轻度的COVID-19可以导致持久的脑部变化和认知问题,即使没有脑雾. 这些长期的COVID影响包括结构性改变和网络异常,影响记忆力和注意力.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 长期COVID是SARS-CoV-2感染后的疾病,可以表现为持续的神经认知缺陷.
- 脑雾是一种常见但不太了解的症状,影响COVID-19幸存者的认知功能.
研究的目的:
- 为了研究神经认知缺陷,结构性大脑变化和轻度SARS-CoV-2感染幸存者的网络异常,有或没有脑雾.
- 为了比较健康对照组之间的这些变化,COVID-19幸存者没有脑雾 (woFOG) 和COVID-19幸存者有脑雾 (wFOG).
主要方法:
- 75名参与者的横截面研究 (24名健康对照,26名woFOG,25名wFOG).
- 神经心理学评估:自由和受制选择性提醒测试 (FCSRT),阿登布鲁克认知检查修订 (ACE-R).
- 神经成像:用于结构性MRI的基于voxel的形态测量 (VBM),用于网络分析的静止状态功能MRI (rs-fMRI).
主要成果:
- 与woFOG和HC组相比,wFOG组在延迟回忆,注意力,记忆和视觉空间技能方面表现出显著的损害.
- 两组COVID-19在和轨道区域的灰质度 (GMC) 都降低了;wFOG还显示基底和杏仁体的GMC减少.
- rs-fMRI揭示了改变的连接:增加默认模式和视觉网络连接,减少COVID-19幸存者的背部注意力网络连接.
结论:
- 即使是轻微的SARS-CoV-2感染也可能导致持续的神经认知缺陷和大脑变化.
- 长期COVID中的大脑雾与更明显的结构和功能性大脑变化有关.
- 研究结果强调,需要长期监测和干预长期COVID的神经后果.
相关概念视频
Long-term Depression
2.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.4K
Long-term Potentiation
54.4K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
54.4K
Immunological Memory
408
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
408
Cognitive Development During Adulthood
22
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
22
Negative and Cognitive Symptoms of Schizophrenia
29
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
29
Pneumonia II: Pathophysiology
175
The pathophysiology of pneumonia involves the following steps:
175


