动脉硬化大动脉组织的化邻近区域在没有增加放射密度的情况下表现出高硬度
Carly L Donahue1, Victor H Barocas1
1Department of Biomedical Engineering, University of Minnesota, Nils Hasselmo Hall, Room 7-115, 312 Church St. SE, Minneapolis, MN, 55455, USA.
概括
动脉硬性化比周围的大动脉组织更为硬和更为放射密. 它们的机械影响超出了可见的界限,在大动脉介质中充当压力度器.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 材料科学 材料科学 材料科学
背景情况:
- 动脉样硬化涉及斑块积累和动脉重塑,导致机械风险,如大动脉硬化,动脉瘤,解剖和破裂.
- 了解动脉样硬化病变的机械性质对于预测心血管事件至关重要.
研究的目的:
- 研究动脉样性病变和相邻的大动脉介质的机械和成像性质.
- 在人类胸前大动脉样本中,将放射密度与局部度相关联.
主要方法:
- 对19个人类胸前大动脉样本的分析.
- 对平面双轴拉伸试验进行反向机械分析,以确定局部刚度.
- 微计算机断层扫描 (micro-CT) 图像检测,以评估辐射密度.
主要成果:
- 化显著比周围的大动脉组织更为辐射密度和硬.
- 放射密度不能可靠地预测非化区域的度.
- 围绕化物观察到显著的刚度梯度,在距离高达5.4毫米时呈指数级下降.
结论:
- 化作用于大动脉中的局部机械应力度器.
- 化的生物力学影响超出了它们的可见边界.
- 微型CT成像在评估软,非化组织中的机械异质性方面存在局限性.
更多相关视频
08:43Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
19.4K
04:30Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
Published on: February 4, 2021
2.5K
相关概念视频
01:20Imaging Studies for Cardiovascular System III: X-Ray
118
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
118
01:38Inflammation
52.1K
Overview
52.1K