微观结构白质完整性降低与功能神经障碍中身体症状的严重程度有关
Nicolas Gninenko1, Eliane Müller2, Selma Aybek1
1Faculty of Science and Medicine, Department of Neurology, University of Fribourg, Fribourg, Switzerland; Department of Neurology, Psychosomatic Medicine Unit, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland.
NeuroImage. Clinical
|May 3, 2025
概括
功能神经障碍 (FND) 涉及广泛的白质变化,特别是在调节情绪和身体意识的区域. 这些变化与症状严重程度相关,可能反映了大脑的可塑性,而不是固定的特征.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 功能神经障碍 (FND) 传统上被视为涉及功能性脑网络变化而没有结构性损伤.
- 新兴研究表明,灰色和白质的解剖学变化也可能导致FND症状.
- 这项研究调查了FND患者的白质完整性.
研究的目的:
- 在大量FND患者的样本中描述白质微观结构完整性.
- 检查白质完整性与身体症状严重程度之间的关联.
- 探索伴随性情绪障碍在这些变化中的作用.
主要方法:
- 从85名FND患者和75名健康对照 (HC) 获得的扩散权重成像 (DWI) 数据.
- 白物质的微观结构完整性使用概率学曲谱和Desikan-Killiany分片计算.
- 分析包括疾病持续时间,临床医生评级 (S-FMDRS,CGI) 和患者报告的 (SF-36) 症状严重程度,调整为抑郁和焦虑.
主要成果:
- 与HC相比,FND患者的白质微结构完整性普遍降低,特别是在右侧轨道前皮层,胰岛,膜和上部区域.
- 在调整抑郁和焦虑后,这些群体差异变得无意义.
- 在FND患者中,左前和左上皮质皮质的微结构完整性降低与身体症状严重程度有很强的相关性.
结论:
- FND与广泛的白质微结构完整性减少有关,特别是在参与情绪调节和身体意识的区域.
- 这些变化部分可以通过伴随性情绪障碍和症状严重程度来解释,这表明大脑潜在的可塑性.
- 需要进一步的纵向研究来证实这些发现并探索它们的含义.
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