下部肌肉的数量作为骨和软组织肉瘤患者整体生存的有希望的预后因素
Tadashi Iwai1, Maria Anna Smolle2, Dominik Kaiser3
1Department of Orthopedic Surgery, Balgrist University Hospital, Forchstrasse 340, Zürich, CH-8008, Switzerland; Department of Orthopedic Surgery, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahi-Machi, Abeno-Ku, Osaka, 545-8585, Japan.
Surgical oncology
|May 3, 2025
概括
腿部肌肉体积减少与成人骨和软组织肉瘤患者的生存率较差有关. 手术后维持肌肉质量可能会改善这些癌症患者的结果.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 手术瘤学手术瘤学
背景情况:
- 骨肉瘤 (BS) 和软组织肉瘤 (STS) 的预后因素得到了充分研究.
- 最近的研究强调了肌肉量对老年癌症患者预后的影响.
- 没有先前的研究检查了腿部肌肉体积与成年BS和STS患者的存活率的关系.
研究的目的:
- 在BS和STS的成年患者中,研究大腿肌体积和整体存活率 (OS),局部无复发存活率 (LRFS) 和无转移存活率 (MFS) 之间的联系.
- 评估成年BS和STS人口中不同年龄组的肌肉量指标.
主要方法:
- 从119名成人BS和STS患者 (2014-2023) 的临床病理学数据的回顾性分析.
- 使用PET-CT成像评估大腿肌量,psoas肌指数和三肌体积.
- 考克斯比例危险回归和卡普兰-梅尔方法用于评估生存率和预后因素.
主要成果:
- 该研究包括119名成年患者,随访时间中位数为34个月.
- 在五年内,OS,LRFS和MFS的五年率分别为73.7%,86.6%和76.7%.
- 多变量分析确定了瘤第四阶段,并降低了全大腿肌肉体积,作为整体存活率差的显著预测因素.
结论:
- 腿部肌肉体积减少是骨和软组织肉瘤的成年患者总生存率下降的重要预后指标.
- 保持术后的股骨肌体积对于改善这些患者的生存结果至关重要.
更多相关视频
相关概念视频
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:21Cancer Survival Analysis
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...