暴露于有机酸盐阻燃剂和酸盐会改变神经元活动和网络发展
Lennart V J van Melis1, Kyra N Zimnik1, Arjuna R Persad1
1Neurotoxicology Research Group, Division of Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, PO Box 80.177, Utrecht NL-3508 TD, the Netherlands.
Toxicology
|May 3, 2025
概括
有机酸盐阻燃剂 (OPFR) 和酸盐会引起神经毒性. 三酸 (TPhP) 和酸改变了大鼠皮层培养中的神经元活动和网络发展,在低度下观察到的效果.
科学领域:
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
- 发展生物学 发展生物学
背景情况:
- 有机酸盐阻燃剂 (OPFR) 和酸盐与神经发育问题有关.
- 这些化学物质会损害神经元功能,学习和记忆.
研究的目的:
- 调查急性和慢性暴露于三酸 (TPhP) 和各种酸盐的神经毒性影响.
- 评估对初级大鼠皮质培养中的神经元活动和网络发展的影响.
主要方法:
- 来自雄性和雌性大鼠的原发皮质培养是在微电极阵列上培养的.
- 神经元被急性和慢性地暴露在TPhP和酸盐 (DEP,DBP,BBzP,DEHP,MEHP) 中.
- 监测神经元活动和网络发展.
主要成果:
- 对TPhP,DEP,DBP和BBzP的急性暴露抑制了神经元活动.
- 长期暴露于TPhP和DEP导致神经元过度兴奋.
- 长期暴露于DBP,BBzP,DEHP和MEHP会影响神经网络的发育.
- 在人体相关度 (1μM) 中,BBzP和DEHP表现出影响.
- 代谢物的影响是有限的.
结论:
- 三酸 (TPhP) 和一些酸具有神经毒性作用.
- 观察到的神经毒性通过非内分泌机制发生.
- 在低,环境相关的度下,影响可能会显现,需要考虑风险评估.
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