在基于人口的队列中,乳制品摄入量,血代谢和2型糖尿病的风险
Shunming Zhang1, Suzanne Janzi2, Yufeng Du2
1School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China; Nutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
The American journal of clinical nutrition
|May 3, 2025
概括
摄入大量非发酵牛奶和奶酪可能会增加2型糖尿病的风险. 相反,发酵牛奶,奶油和黄油表现出相反的关联,这表明乳制品对糖尿病风险的代谢影响不同.
科学领域:
- 营养流行病学 营养流行病学
- 代谢学 代谢学 代谢学
- 慢性疾病研究 慢性疾病研究
背景情况:
- 乳制品消费与2型糖尿病 (T2D) 风险之间的关系尚未完全理解.
- 潜在的代谢途径将乳制品摄入量与T2D联系起来需要进一步调查.
研究的目的:
- 调查瑞典人口中高乳制品摄入量与T2D风险之间的关联.
- 为了确定与不同类型的乳制品消费相关的血代谢物.
主要方法:
- 对26461名瑞典成年人的前性队列研究,长期跟踪 (直到2020年).
- 在基线评估的乳制品摄入量;通过链接的注册表追踪T2D发病率.
- 在亚样本 (n=893) 中使用质谱分析分析的等离子体代谢物.
- 考克斯的比例危险模型用于评估关联.
主要成果:
- 与高摄入非发酵牛奶和奶酪相关的T2D风险增加.
- 在摄入大量发酵牛奶,奶油和黄油时观察到T2D风险降低.
- 确定了每个乳制品类型的独特代谢物概况,没有重叠.
结论:
- 高度的非发酵牛奶和奶酪消费与T2D风险有关.
- 高度的发酵牛奶,奶油和黄油消费与T2D风险相反相关.
- 代谢学为乳制品与T2D关联的代谢基础提供了新的视角.
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