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急性淋巴细胞白血病与T-和B-血统定义标记

Shuyu E¹, Fatima Z Jelloul¹, Karen A Nahmod¹

¹Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

|May 3, 2025

概括

大多数具有T细胞 (cCD3) 和B细胞 (CD19) 标记的急性淋巴细胞白血病 (ALL) 病例是早期的T前体ALL,具有异常的B细胞标记,而不是真正的混合T/B-ALL. CD19表达在复发中持续存在,有助于检测和治疗.

科学领域:

血液学血液学血液学
在瘤学瘤学.
免疫型定型免疫型定型

背景情况:

细胞质CD3 (cCD3) 定义了T系,CD19定义了B系急性淋巴细胞白血病 (ALL).
在所有情况下,在cCD3和CD19两种共同表达的情况下,谱系分配可能具有挑战性.

研究的目的:

研究cCD3和CD19共同表达ALL病例的免疫表型和遗传特征.
为了确定混合T/B血统ALL的频率和性质.
评估CD19在复发/残留疾病中的作用.

主要方法:

流细胞测量用于免疫类型 (cCD3,CD19,其他B细胞标记物).
基因分析包括IgH/IgK/L和TRG/TRB重组.
检测常见的T-ALL遗传异常 (例如,NOTCH1突变,PHF6缺失).

主要成果:

23 所有的病例 (大约. 10%的cCD3+ALL) 与cCD3和CD19共同表达,还有额外的B细胞标记物 (CD79a,PAX5,CD22,CD10).
真的混合T/B血统ALL很少发生 (2例),与BCR::ABL1.1相关.
大多数病例显示T-ALL遗传特征与异常的B细胞标志物表达.
CD19在复发/残留疾病中持续表达 (94%).

结论:

大多数cCD3+/CD19+ALL病例代表早期T前体ALL与异常的B细胞标志物表达,而不是真正的混合血统白血病.
BCR::ABL1重新排列与罕见的混合T/B-ALL有关.
在复发/残留疾病中持续的CD19表达突显了其作为治疗标和诊断标记物的潜力.

关键词:

B细胞标记物是B细胞的标记物.在CD2222中,我们可以看到CD22.在IgH和IgH之间.在T-淋巴细胞白血病.在TCR中,可以使用TCR.混合表型急性白血病混合表型急性白血病

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