nebulized dexmedetomidine 对胃肠内镜治疗的儿科患者的吐反射抑制和镇静质量的影响:一项随机对照试验
Esra Turunc1, Yasemin Burcu Ustun2, Sezgin Bilgin2
1Department of Anesthesiology and Reanimation, Faculty of Medicine, Ondokuz Mayis University, Kurupelit, Samsun, TR55139, Turkey. esra.kiymaz.ek@gmail.com.
BMC anesthesiology
|May 3, 2025
概括
雾化德克斯梅德托米丁显著减少了儿科内镜患者的吐和咳反射. 这种安全有效的前期治疗改善了患者的舒适度和程序的成功.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 儿科上部胃肠道 (GI) 内镜经常需要镇静和止痛.
- 反射在儿童内镜探针放置期间是一个重大挑战.
- 有效地管理反射对于成功的儿科胃肠道手术至关重要.
研究的目的:
- 为了研究 nebulized dexmedetomidine作为前期治疗在接受上肠道内镜检查的儿科患者的疗效.
- 评估 nebulized dexmedetomidine 在儿科内镜检查期间对吐反射严重性的影响.
- 评估二次结果,包括咳,焦虑,兴奋和内镜师的满意度.
主要方法:
- 进行了一项单中心,前性,随机对照试验,涉及2至17岁的儿科患者.
- 参与者被随机分配到接受 nebulized dexmedetomidine (2μg/kg) 或没有预先治疗.
- 喉反射的严重程度是主要结果;咳,焦虑,激动和满意是次要结果.
主要成果:
- 雾化德克斯梅德托米丁显著降低了反射发生率 (88.3%对比30%,p<0.001) 和咳 (95%对比55%,p<0.001).
- 德克斯梅德托米丁组的分离焦虑得分明显较低 (p<0.005).
- 观察到对额外麻醉剂的需求减少和更高的内镜师满意度,并没有显著增加并发症.
结论:
- nebulized dexmedetomidine 是用于儿科内镜的安全有效的前期药物.
- 它显著减轻了吐和咳反射,提高了患者的舒适性和程序安全性.
- 这种方法提高了内镜师的满意度,并减少了儿童胃肠道手术中的麻醉要求.
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