在患有先天性CMV感染的儿童中,细胞巨乳病毒唾液流放动力学
Swetha Pinninti1, Sunil Pati1, Zdenek Novak2,1
1Department of Pediatrics, Heersink School of Medicine, University of Alabama at Birmingham.
概括
在通过新生儿查发现的婴儿中,先天性CMV (cCMV) DNA在唾液中流失的时间平均为20个月. 无论最初的症状或听力损失,流产的持续时间都相似,在三分之一的病例中观察到间歇性流产.
科学领域:
- 病毒学 病毒学
- 儿科 儿科 儿科
- 公共卫生 公共卫生
背景情况:
- 遗传性细胞大脑病毒 (cCMV) 是儿童非遗传性神经感官听力损失的主要原因.
- 由于新生儿查和随访不一致,对婴儿的CMV流放动力学数据有限.
- 全球新生儿查可以更好地了解cCMV的自然史.
研究的目的:
- 描述CMVDNA在cCMV感染婴儿的唾液中的自然史.
- 描述cCMV队列中的流产时间,病毒载量和模式 (连续或间歇).
- 根据新生儿症状的存在和听力结果来比较流产动力学.
主要方法:
- 从全方位新生儿查计划 (CHIMES研究) 中对197名确诊cCMV的婴儿进行前性随访.
- 四年来,每六个月收集一次的唾液样本,以评估CMV DNA泄漏动力学.
- 分析包括流产时间,病毒载量和间歇性流产模式,比较有症状和无症状的婴儿,以及有和没有听力损失的婴儿.
主要成果:
- 在唾液中检测到CMVDNA的时间平均为20个月,随着时间的推移,泄露量会减少.
- 从确认到4年随访期间,病毒载量的中位数显著下降.
- 在有或没有新生儿症状的婴儿和有或没有神经感官听力损失的婴儿中,流产的持续时间类似.
- 间歇性CMVDNA脱落发生在32.5%的队列中.
结论:
- 在通过普遍查识别的cCMV的婴儿中,CMV DNA在唾液中流失持续时间平均为20个月.
- 流产时间不受新生儿症状的存在或听力损失的发展的影响.
- 间歇性流产是cCMV.婴儿中常见的模式.
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