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乳房主要肌肉质量减少在叶片切除术后对肺癌预后的影响

Risa Kuboi¹, Norifumi Tsubokawa¹, Atsushi Kamigaichi¹

¹Department of Surgical Oncology, Hiroshima University, 1-2-3 Kasumi, Minami Ward, Hiroshima City, Hiroshima 734-8551, Japan.

Japanese journal of clinical oncology

|May 4, 2025

概括

肺癌手术后胸部主要肌肉质量的术后损失与更糟糕的生存结果有关. 手术后监测肌肉质量对于非小细胞肺癌患者至关重要.

科学领域:

胸部外科手术胸部外科手术
手术瘤学手术瘤学
肺部医学肺部医学

背景情况:

手术前低骨肌量是已知的非小细胞肺癌 (NSCLC) 的负预后因素.
对于NSCLC手术后发生的骨肌肉损失的临床影响尚不清楚.
这项研究检查了术后胸部主要肌肉质量下降的预后意义.

研究的目的:

为了研究乳房主要肌肉质量减少12个月后的乳房切除术和长期患者结果之间的关联.
确定术后肌肉损失是否是NSCLC患者生存的独立预测因素.

主要方法:

对460名患有病理性I-II期NSCLC的患者进行了回顾性分析,这些患者接受了带切除术.
根据手术后12个月的胸部主要肌肉质量变化率 (截止值:0.94),患者被分为两组.
评估了长期结果,包括整体存活率和慢性阻塞性肺病 (COPD) 的发病率.

主要成果:

在126名患者中观察到胸部主要肌肉质量的减少.
肌肉质量减少组的COPD发病率高于没有肌肉质量减少组.
在术后肌肉减少的患者中,整体存活率明显较低 (P < .001).
多变量分析确定胸部主要肌肉质量减少是整体存活时间的独立负预后因素 (HR,1.05;P <.001).

结论:

脑膜切除术后胸部主要肌肉质量的减少与NSCLC患者的预后较差有关.
手术后的骨肌损失,特别是在大胸部,是长期结果的重要指标.

关键词:

肺癌是一种肺癌.非小细胞肺癌的肺癌.术后并发症术后并发症这种类型的麻症是sarcopenia.

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