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Updated: May 23, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
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皮拉佐罗[1,5-a]皮里米丁基I型光敏感剂作为一种有效的亡诱导剂,用于瘤切除

Shuo Zhang1, Jingru Qiu1, Hao Zhang1

  • 1Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province 250012, P. R. China.

Journal of medicinal chemistry
|May 4, 2025
PubMed
概括

研究人员开发了新的pyrazolo[1,5-a]pyrimidine光敏感剂,以诱导 pyroptosis,一种增强抗瘤免疫力的细胞死亡形式. 化合物ZS-3通过caspase-3/GSDME通路有效触发热,显示癌症光动力学治疗的希望.

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