在COVID后综合征中,认知障碍和相关的神经行为功能障碍
Laura Marie Schmidt1, Carsten Klingner2, Insa Petersen1
1Biomagnetic Center, Jena University Hospital, Jena, Germany; Friedrich Schiller University Jena, Jena, Germany.
Psychiatry research
|May 4, 2025
概括
后COVID综合征可能不会影响奖励处理,但会导致神经性低兴奋. 这导致认知功能减慢,前脑区域大脑活动发生变化,影响长期COVID患者.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 传染性疾病 传染性疾病
背景情况:
- 后COVID综合征经常出现神经精神疾病症状,如慢性疲劳.
- 潜在的机制,特别是关于大脑的奖励系统,还不太清楚.
- 改变奖励处理被假设为长期COVID中认知缺陷的潜在原因.
研究的目的:
- 调查后COVID综合征是否会影响奖励处理或非特定任务的认知操作.
- 要区分奖励回路的缺陷与更广泛的认知控制机制之间的差异.
- 探索长期COVID患者认知功能障碍的神经基础.
主要方法:
- 一项队列研究比较了24名COVID后综合征患者与24名健康对照.
- 在功能磁共振成像 (fMRI) 期间使用货币激励延迟任务.
- 包含神经精神病症状问卷和瞳孔测量.
主要成果:
- 后COVID患者的任务表现较慢,但行为奖励回路功能完好无损.
- 随着时间的推移,奖励线索的影响增加与左前额回路激活延迟相关.
- 反应时间较慢与瞳孔直径减少和瞳孔不安程度较高有关.
结论:
- 后COVID综合征可能不会直接影响奖励处理机制.
- 研究结果表明,神经过度兴奋和暂时改变脑活动在额头和任务非特定区域.
- 这表明改变认知控制和兴奋状态是长期COVID神经影响的关键特征.
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