增加肠粘膜透性和代谢性内毒性预测心血管死亡风险
J Parantainen1, G Barreto2, T E Strandberg3
1Department of Rheumatology, University of Helsinki and Helsinki University Hospital, Helsinki, HUS 00029, Finland; Translational Immunology Research Program (TRIMM), Research Program Unit (RPU), University of Helsinki, 00014, Helsinki, Finland.
增加的肠道透性和代谢性内毒性,以佐努林为指标,与较高的心血管疾病死亡率有关. 这些生物标志物可以作为动脉样硬化心血管疾病风险的稳定指标.
科学领域:
- 心血管科学 心血管科学
- 胃肠病学 胃肠病学
- 炎症研究 炎症研究
背景情况:
- 低度慢性炎症是动脉样硬化心血管疾病 (ASCVD) 的关键因素.
- 关联炎症与ASCVD的机制,特别是涉及肠道,需要进一步阐明.
- 肠道透性和代谢性内毒性是ASCVD病因的潜在贡献者.
研究的目的:
- 调查肠道透性和代谢性内毒性作为心血管死亡风险因素的作用.
- 评估特定生物标志物对ASCVD结果的预测价值.
- 在15年的随访期内检查这些生物标志物的稳定性.
主要方法:
- 来自赫尔辛基商人研究 (HBS) 的子队列的分析与长期随访.
- 测量了6种肠道透性和内毒素的生物标志物.
- 生物标志物水平与ASCVD流行率,常规风险因素和死亡率数据的相关性.
主要成果:
- 佐努林,脂多糖结合蛋白 (LBP) 和肠脂肪酸结合蛋白 (I-FABP) 在15年内显示出个人水平的相关性.
- 较高的佐努林和LBP水平与冠状动脉疾病 (CAD) 死亡的10年风险增加有关.
- 佐努林与几种传统的ASCVD风险因素相关联.
结论:
- 代谢性内毒症被认为是导致ASCVD的因素,具有不良后果.
- 在研究的生物标志物中,佐努林成为CAD死亡率的强有力的预测因素.
- 随着时间的推移,佐努林,LBP和I-FABP水平保持稳定,这表明它们作为ASCVD风险生物标志物的潜力.
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