精液等离子体金属混合物与精液质量之间的关联:一种代谢组介导的病例控制研究
Shujie Zhao1, Wenrui Lu2, Guanxiang Yuan3
1Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology, Shenzhen Center for Disease Control and Prevention, 8 Longyuan Rd, Shenzhen, Guangdong 518055, China.
Ecotoxicology and environmental safety
|May 4, 2025
概括
精液中的金属混合物增加了异常精液质量 (ASQ) 的风险. 铜 (Cu) 增加ASQ风险,而铁 (Fe) 和 (Se) 则表现出通过特定代谢物介导的保护作用.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 代谢学 代谢学 代谢学
背景情况:
- 暴露于金属是与男性不孕症相关的全球性问题.
- 了解污染物与生物系统的相互作用对于生殖健康至关重要.
研究的目的:
- 研究多金属暴露,精液等离子体代谢物和异常精液质量 (ASQ) 之间的关系.
- 确定介导这些关联的特定代谢物.
主要方法:
- 在522名男性的匹配病例控制研究中.
- 对265种精液等离子体代谢物进行非向的代谢分析.
- 使用后勤回归,量子差距累积 (QG-C),加权量子和 (WQS) 和贝叶斯内核机器回归 (BKMR) 的分析.
主要成果:
- 金属混合物总体上增加了ASQ风险.
- 精子中的铜 (Cu) 显著增加了ASQ风险.
- 铁 (Fe) 和 (Se) 显示出保护性的趋势.
- 确定了74种差异性代谢物,其中特定的代谢物介导金属-ASQ关联.
结论:
- 精液等离子金属通过特定代谢物通路破坏男性生育能力.
- 铜驱动损坏,而铁和提供保护.
- 确定了男性生殖健康的候选生物标志物和可信的干预途径.
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