单细胞转录组学揭示了化疗免疫治疗对下喉癌及其瘤微环境的影响
Xiaoli Zhu1, Haibo Xu2, Yulan Zhao3
1Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Oral oncology
|May 4, 2025
概括
鉴定下癌 (HPC) 治疗耐药性的预测标志物至关重要. 这项研究揭示了瘤微环境异质性和S100A2基因表达是诱导化疗免疫疗法 (ICIT) 反应的关键指标.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 癌症基因组学 癌症基因组学
背景情况:
- 诱导化疗免疫疗法 (ICIT) 是对可切除的下喉癌 (HPC) 的潜在治疗方法.
- 治疗的有效性各不相同,需要标记物来预测耐药性.
- 缺乏可靠的分子标记物阻碍了个性化治疗策略.
研究的目的:
- 为了确定分子和细胞标记物,预测接受ICIT的HPC患者的治疗反应.
- 研究瘤微环境 (TME) 在ICIT疗效中的作用.
- 能够及早识别耐治疗患者,以优化治疗方法.
主要方法:
- 在ICIT之前和之后对HPC患者活检样本的分析,按治疗反应分类.
- 瘤微环境 (TME) 的单细胞水平调查.
- 大量RNA测序用于细胞组成估计和蛋白质水平验证.
主要成果:
- 瘤微环境的异质性与不同的治疗结果相关.
- 癌症相关纤维细胞 (CAFs) 的特定亚群与强烈的治疗反应有关.
- 瘤细胞中的高S100A2基因表达与ICIT疗效有关.
结论:
- 这是一种新的方法来识别基因和细胞群,从而预测HPC中的ICIT反应.
- 及时识别治疗耐药患者的潜力.
- 提高喉功能保存的可能性和优化治疗策略.
相关概念视频
02:49Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
02:17The Tumor Microenvironment
6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
01:27Tumor Immunotherapy
450
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
450
02:53Adaptive Mechanisms in Cancer Cells
5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K