暴露于细颗粒物和多个时间段的感冒对流感的相互作用:一个多中心病例交叉研究
Shouxin Peng1, Bin Fang2, Siyu Gan1
1Global Health Department, School of Public Health, Wuhan University, Wuhan, Hubei 430071, China.
Journal of hazardous materials
|May 4, 2025
概括
空气污染 (PM2.5) 和感冒 (CS) 会增加流感风险. 这些环境因素在协同作用下相互作用,特别是在夜间寒冷期间,引发流感流行病.
科学领域:
- 环境流行病学环境流行病学
- 公共卫生 公共卫生
- 传染病的动态传染病的动态.
背景情况:
- 气候变化和空气污染是全球日益关注的问题.
- 有证据表明,环境暴露可能会影响流感流行病.
- 空气污染和感冒对流感的协同影响仍然不清楚.
研究的目的:
- 调查颗粒物2.5 (PM2.5) 和感冒 (CS) 对流感风险的综合影响.
- 评估PM2.5和CS之间在引发流感时的潜在协同作用.
主要方法:
- 采用了一个案例交叉研究设计.
- 分析了湖北省13972名实验室诊断的流感患者 (2011-2018) 的数据.
- 条件后勤回归模型评估了PM2.5和CS暴露的影响,计算了相互作用效应.
主要成果:
- 无论是PM2.5还是CS都与流感风险增加有显著的关联.
- PM2.5的四分位数间范围增加与流感风险增加8%相关.
- 寒冷时期的风险显著增加:整体 (18%),白天 (16%),夜间 (28%).
- 在PM2.5和CS之间发现了显著的协同效应,特别是夜间的CS (由于相互作用的相对过度风险=0.26).
结论:
- 暴露于PM2.5和CS,特别是夜间的CS,会增加流感风险.
- PM2.5和CS表现出协同效应,表明它们的综合影响大于它们的单个效应的总和.
- 调查结果强调了在流感预防策略中考虑组合环境暴露的重要性.
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