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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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转化手术中的猪模型

Rebecca Goutchtat, Axelle Béguier, Nathalie Kasal-Hoc

    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
    |May 4, 2025
    PubMed
    概括

    猪模型对于外科研究至关重要,因为它与人类的解剖学相似之处,推进了诸如心血管和消化器官手术等领域. 未来的研究将集中在异种移植和伦理考虑上.

    科学领域:

    • 生物医学工程 生物医学工程
    • 翻译外科手术 翻译外科手术
    • 比较解剖学的比较解剖学

    背景情况:

    • 由于尺寸的限制,动物模型对人类外科翻译是有限的.
    • 猪在外科研究中具有显著的翻译价值,因为它们与人类的解剖学和生理学相似.

    研究的目的:

    • 审查猪模型在各种外科研究领域的多样化应用和未来潜力.
    • 突出猪在促进心血管,消化,内分泌,骨关节和神经外科手术方面的作用.
    • 讨论从猪移植到人类的异种移植及其道德方面的影响.

    主要方法:

    • 在手术研究中使用猪模型的研究的文献综述.
    • 分析不同外科专业的猪模型贡献.
    • 检查当前和未来的趋势,包括异种移植和机器人手术.

    主要成果:

    • 猪在开发支架,改善旁路移植和推进心脏门外移植方面发挥了重要作用.
    • 猪模型有助于用于腹部修复,肝脏再生研究和代谢手术研究的网格开发.
    • 骨关节和神经外科的使用越来越多,对于测试外科设备,最小入侵技术和机器人手术培训至关重要.

    结论:

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    • 猪模型对手术研究的进步做出了重大贡献,特别是在异种移植方面.
    • 未来的研究将专注于改进猪模型,以提高临床前可靠性,并解决道德问题.
    • 猪对人类的异种移植显示出希望,但需要进一步研究长期的安全性和有效性.