胃癌
Raghav Sundar1, Izuma Nakayama2, Sheraz R Markar3
1Department of Medicine, Section of Medical Oncology, Yale School of Medicine, New Haven, CT, USA; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore.
Lancet (London, England)
|May 4, 2025
概括
胃癌是一个全球性的健康问题, 包括手术,免疫疗法和精确医学在内的治疗进步旨在改善患者的生存率和生活质量.
科学领域:
- 癌症学
- 胃肠病学
- 公共卫生
背景情况:
- 胃癌对全球健康造成重大负担,死亡率高,地理发病率差异显著.
- 这种疾病越来越多地影响50岁以下的人,
- 确定的危险因素包括Helicobacter pylori感染,生活方式 (饮食,肥胖,吸烟) 和遗传易感性.
研究的目的:
- 提供关于胃癌管理现状的全面概述.
- 突出治疗方式和新兴治疗策略的最新进展.
- 通过精准医学和早期检测来改善胃癌的未来方向.
主要方法:
- 对胃癌发病率和死亡率的当前流行病学数据的审查.
- 对局部晚期和晚期胃癌的标准和新兴治疗方案的分析.
- 探索新的诊断和治疗方法,包括免疫治疗和向治疗.
主要成果:
- 胃癌的发病率在地理位置上有所不同,早期发病率上升.
- 标准治疗包括手术 (D2淋巴切除术),化疗和放射治疗.
- 最少侵入性手术,免疫检查点抑制剂和向治疗越来越多地用于可手术和晚期疾病.
结论:
- 早期发现和全面诊断对于优化治疗至关重要.
- 针对性治疗和新一代免疫疗法等新兴疗法有望改善存活率.
- 未来的管理策略强调精确医学,免疫疗法,早期检测和多学科护理,以提高整体有效性和预后.
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