预防性蒙特卢卡斯特及其对下第三手术后临床结果的影响:一项三盲随机对照试验
Jitendra Chawla1, M A Bari Siddiqui2, Yerragudi Navaneeth3
1Associate Professor, Department of Dentistry, All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, India.
概括
预防性 etoricoxib 有效地减少了第三手术后的疼痛. 蒙特卢卡斯特显示出抗炎作用,但两种替代疗法都不支持标准治疗.
科学领域:
- 口腔和牙面部外科手术
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 循环氧化原酶 (COX) 抑制剂用于 mandibular 第三提取后的疼痛和胀.
- 在这种情况下,氧酶 (LOX) 途径抑制剂,如蒙特卢卡斯特 (Montelukast) 的作用仍未得到充分研究.
研究的目的:
- 为了比较单次预防剂量蒙特卢卡斯特和埃托利可西布在治疗术后疼痛方面的疗效.
- 评估它们对炎症标志物和患者康复的影响.
主要方法:
- 进行了一项三重盲目,安慰剂控制的随机临床试验.
- 48名接受受冲击的第三骨抽取的患者被随机分为三组:蒙特卢卡斯特,埃托利可西布或安慰剂.
- 在7天内使用视觉模拟量表 (VAS) 测量疼痛强度;还评估了瘤缩因子-α (TNF-α) 水平,救援止痛,胀和三.
主要成果:
- 与蒙特卢卡斯特和安慰剂 (P = .01) 相比,埃托里科西布在2小时内显示出明显较低的术后疼痛得分.
- 观察到时间和治疗组之间的显著相互作用 (P = .008),表明随着时间的推移治疗效果有所不同.
- 蒙特卢卡斯特显示了减少炎症和调节TNF-α水平的趋势,尽管在提供的结果摘要中没有明确详细说明.
结论:
- 预防性埃托里科克西布有效地减少了第三手术后的术后疼痛.
- 蒙特卢卡斯特可能具有抗炎性质,可能调节TNF-α.
- 该研究不支持使用这些特定的替代先发制止止痛疗法而不是标准护理.
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