童年逆境作为自身免疫性疾病的风险因素:系统性审查和元分析,对精神病学产生影响
Jehanita Jesuthasan1, Cameron J Watson2, Danish Hafeez3
1Institute of Cognitive Neuroscience, Division of Psychology and Language Sciences, University College London, London, UK; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Brain, behavior, and immunity
|May 4, 2025
概括
童年逆境与成人自身免疫性疾病有关,包括类风湿性关节炎和牛皮. 虽然有证据表明存在联系,但高异质性和偏见风险需要谨慎解释研究结果.
科学领域:
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 自身免疫性疾病源于破坏免疫调节的遗传和环境因素.
- 童年逆境是影响免疫系统发育的重要环境风险因素.
- 逆境的长期影响表明它可能在自身免疫性疾病病因学中起作用.
研究的目的:
- 系统地审查和元分析童年逆境与成年期自身免疫性疾病之间的关联.
- 整合来自不同研究的证据,以量化这种关系.
- 为了确定与童年逆境相关的特定自身免疫疾病.
主要方法:
- 在主要电子数据库 (MEDLINE,PsycINFO,Embase,Web of Science) 进行系统搜索.
- 包括英语同行评审的研究,重点关注自免疫诊断的成年人童年逆境率.
- 来自27项研究的45个效果大小的元分析 (8,728例,3,298,392对照).
主要成果:
- 发现了一种小但显著的效应 (SMD = 0.30),将童年逆境与成人自身免疫性疾病联系起来.
- 诸如类风湿性关节炎,牛皮,多发性硬化症和炎症性肠道疾病等特定疾病显示出显著的关联.
- 发现了高度的异质性和潜在的出版偏差;21项研究具有高偏差风险.
结论:
- 有证据支持童年逆境和自身免疫性疾病之间的关联.
- 这种联系可能会导致自身免疫性疾病和严重精神疾病的并发症.
- 由于证据异质性和研究偏见,结果需要谨慎解释;潜在的机制和预防策略需要进一步调查.
相关概念视频
01:29Psychological and Sociocultural Causes of Schizophrenia
39
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
39
01:29Autoimmune Disorders
348
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
348
01:30Attention-Deficit/Hyperactivity Disorder
33
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
33
01:27Psychoneuroimmunology: Cardiovascular Disease
21
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
21
01:28Adler's Individual Psychology
391
Alfred Adler, a prominent figure in psychology, founded the school of individual psychology. In contrast to Freud's emphasis on sexual or aggressive motives, Adler suggested that individuals are primarily motivated by their purposes and goals. He believed that people strive for perfection rather than pleasure. Adler argued that individuals could creatively act upon their genetic inheritance and environmental experiences to shape their own lives, emphasizing conscious motivation over...
391
01:19Autism Spectrum Disorder
48
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
48