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3D打印的可膠片:在兒童群體中,為口服阿莫西西林的新工具

Anna Imbriano¹, Costanza Fratini², Giulia Bondi³

¹Department of Pharmaceutical Sciences, University of Perugia, via del liceo 1 - 06123 Perugia, Italy.

International journal of pharmaceutics

|May 4, 2025

概括

创新的3D打印可口香糖片为儿科阿莫西西林 (抗生素) 管理提供了可口的替代方案. 这种新的配方提高了患者的接受度,并确保了有效的药物输送,克服了传统药物的挑战.

科学领域:

制药技术制药技术制药技术
材料科学材料科学材料科学
儿科医学儿科医学

背景情况:

氨基是一种广泛的儿童抗生素,但现有的配方如悬浮剂和片剂往往面临患者接受度较低,导致治疗失败.
改善儿科药物的口感和易于服用对于有效的治疗结果至关重要.

研究的目的:

开发和表征一种创新的,3D打印的可口香糖片配方的阿莫西西林,用于儿科.
评估新型配方的可接受性,机械性能和药物释放概况.

主要方法:

利用压力辅助微注射3D打印技术,制造可的口香糖片.
采用玉米粉和秋蜂蜜的凝矩阵作为3D打印的"墨水".
评估视觉吸引力,尺寸精度,机械性能 (硬度,性),体外药物释放和通过人工膜的透.

主要成果:

优化的3D打印片含有200毫克的阿莫西西林,在视觉上具有吸引力,并且在设计和产品之间显示出高准确性.
在模拟的唾液条件下,机械性能,包括硬度和性,被发现是可以接受的.
片在模拟的胃环境中在2小时内几乎完全释放了阿莫西西林,并证实了药物透.

结论:

3D打印是一种多功能和可扩展的技术,用于为儿科患者创建定制,可口味的口服配方.
这些新的3D打印的阿莫西西林片代表了传统配方的有希望的替代品,可能会改善儿童的治疗遵从性和治疗结果.

关键词:

通过3D打印打印3D打印.氨基氨基酸是什么氨基酸是什么片是一种片.儿科配方儿科配方儿科配方个性化医疗是个性化的医疗.粉是一种粉.

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