心脏代谢指数与中风风险的关联:系统性审查和元分析
Prakasini Satapathy1, Muhammed Shabil2, Mahalaqua Nazli Khatib3
1Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Faculty of Data Science and Information Technology, INTI International University, Nilai, Malaysia.
升高的心脏代谢指数 (CMI) 显著增加了中风风险. 这一综合性措施整合了关键的心血管和代谢因素,有助于早期识别中风风险和预防策略.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 脑卒中是全球主要的健康问题,具有显著的发病率和死亡率.
- 心血管和代谢风险因素,如糖尿病,高血压,肥胖和脂质失调,与中风风险增加有关.
- 心脏代谢指数 (CMI) 将这些因素整合到一个单一的预测指标中.
研究的目的:
- 系统地审查和元分析心脏代谢指数 (CMI) 和中风风险之间的关联.
- 评估CMI对中风发生率的预测值.
主要方法:
- 在PubMed,Embase和Web of Science的系统文献搜索.
- 包括报告CMI和中风风险数据的观察性研究.
- 使用随机效应模型对超过10万名参与者的数据进行元分析.
主要成果:
- 在CMI升高和中风风险增加之间发现了显著的关联 (合并RR1.66,95%CI:1.25至2.20).
- 队列研究显示出类似的关联 (汇总HR为1.63,95%CI为1.21至2.21).
- 在包括的研究中没有观察到显著的异质性 (I2 = 0%).
结论:
- 升高的CMI是增加中风风险的强有力的预测因素.
- CMI提供了综合心血管和代谢风险的综合评估.
- 将CMI整合到健康查中可以改善中风的早期发现和预防.
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