预后营养指数作为住院患者中严重COVID-19感染的风险因素:多中心历史队列研究
Ashish Bhargava1, Susan Szpunar2, Louis Saravolatz1
1Department of Internal Medicine, Wayne State University, Detroit, MI, USA; Division of Infectious Disease, Department of Internal Medicine, Henry Ford Health - St John Hospital, Detroit, MI, USA; Thomas Mackey Center for Infectious Disease Research, Henry Ford Health - St John Hospital, Detroit, MI, USA.
营养不良显著恶化了COVID-19的结果. 预后营养指数 (PNI) 是严重COVID-19的独立预测指标,有助于识别高风险患者.
科学领域:
- 传染性疾病 传染性疾病
- 临床营养学 临床营养学
- 关键护理医学 关键护理医学
背景情况:
- 营养不良是COVID-19结果的一个关键因素,增加死亡风险.
- 预后营养指数 (PNI) 评估营养和免疫状态,与疾病严重程度相关.
研究的目的:
- 为了确定PNI是否独立预测住院美国患者的COVID-19严重程度.
- 评估PNI作为COVID-19患者的风险分层工具.
主要方法:
- 密歇根州286名成年COVID-19患者的历史队列研究.
- 使用SPSS v. 29.0.0.使用电子医疗记录分析的数据.
- 统计学意义设置为p < 0.05.05.
主要成果:
- 在50.3%的患者中诊断出严重的COVID-19.
- 患有严重疾病的患者的PNI平均水平明显较低 (35.1 ± 5.2 与 37.7 ± 6.4 相比,p < 0.001).
- 在对混因子进行调整 (OR=0.92,p < 0.001) 后,PNI仍然是严重/危急COVID-19的独立预测因子.
结论:
- PNI是严重的COVID-19的独立预测器.
- PNI提供了一种简单的风险分层方法,用于医院住院的COVID-19患者.
- 建议进行进一步的研究以验证这些发现.
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