经过透气管肺置换的Fallot四重症患者中期心室功能:与基线右心室负荷条件的关系
Fatima I Lunze1, Susan M Dusenbery2, Kimberlee Gauvreau3
1Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Charité, Charité, Berlin, Germany; Universitätsmedizin Berlin, Germany; Departments of Cardiology, Boston Children's Hospital, Boston, USA.
International journal of cardiology
|May 4, 2025
概括
透气管肺置换改善了修复的Fallot四重症患者的缩功能. 然而,在10年后,只有13.4%的患者没有重新介入.
科学领域:
- 心脏病学 心脏病学
- 儿童心脏病学 儿童心脏病学
- 干预心脏病学 干预心脏病学
背景情况:
- 费洛特四重症 (TOF) 修复往往导致肺狭窄症 (PS) 或吐 (PR).
- 透气管肺置换 (TPVR) 是这些并发症的治疗选择.
- 在TOF患者中TPVR的中期结果需要进一步调查.
研究的目的:
- 为了评估对TPVR的中期缩心室反应.
- 为了比较PS,PR和混合 (PR和PS) 条件的患者之间的结果.
主要方法:
- 63名经过修复的TOF接受TPVR (2007-2011) 的患者的回顾性分析.
- 收集了连续临床,心声和心肺运动测试数据.
- 患者被分为PS,PR和混合子组.
主要成果:
- 与PS和MIXED亚组相比,PR患者的基线左心室 (LV) 功能和运动能力较低.
- 在所有组中,双全球纵向菌株 (GLS) 在TPVR后得到改善,除了MIXED亚组中的LV GLS外.
- 在TPVR后没有观察到运动参数的显著变化,10年无需重新干预的比例为13.4%.
结论:
- 在所有TOF亚组中,TPVR通过中期随访使缩功能正常化.
- 患有PR的患者最初显示LV缩功能和运动能力的缺陷.
- 在该人群中,长期重新干预率在TPVR后仍然是一个重大问题.
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