在患有鼻癌的患者中,辐射诱导的鼻炎
Si-Yuan Chen1, Xiao-Tong Duan2, Rui-Ling Xie2
1Nasopharyngeal Carcinoma Center, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.
鼻癌的放射治疗通常会导致辐射诱导的鼻炎 (RiRS). 对鼻和基线炎症的高辐射剂量增加了RiRS风险,影响了患者的生活质量.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 放射治疗是鼻癌 (NPC) 的首要治疗方法.
- 放射治疗对NPC患者鼻腔粘膜的影响尚不清楚.
- 辐射诱导的鼻炎 (RiRS) 是一个潜在的并发症.
研究的目的:
- 在NPC患者的放射治疗前和之后,研究鼻粘膜炎症的进展.
- 确定影响RiRS发展和进展的因素.
- 开发一个RiRS的预测模型.
主要方法:
- 对1410名NPC患者进行前性队列研究.
- 使用隆德-麦凯分数 (Lund-Mackay score,简称LMS) 评估RiRS.
- 使用临床病理学,放射学和剂量计因素开发和验证预测模型.
- 对于LMS轨迹的潜阶级增长分析.
主要成果:
- 鼻炎的患病率从RT前的7.5%增加到RT后的47.2%.
- RiRS的关键预测因素包括鼻的V30Gy,RT前的LMS异常,以及瘤入侵状底部.
- 确定了三种不同的RiRS进展轨迹.
- V70Gy与LMS轨迹有关.
结论:
- 辐射诱导的鼻炎是NPC患者放射治疗后的常见并发症.
- 鼻辐射剂量,基线鼻粘膜状况和瘤入侵是重要的影响因素.
- 接受高剂量辐射到大鼻腔体积的患者患RiRS的风险更高.
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