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同时和同步的运动皮层甲基突发刺激和上肢神经肌肉电刺激的剂量持续时间效应

Na Cao¹, Atsushi Sasaki², Milos R Popovic³

¹Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, Japan; Japan Society for the Promotion of Science, Chiyoda, Tokyo, Japan.

|May 4, 2025

概括

增加间歇性甲爆刺激 (iTBS) 与神经肌肉电刺激 (NMES) 的剂量-持续时间显著延长皮质脊髓促进. 这种结合的iTBS-NMES方法显示了持续神经调节效应的潜力.

科学领域:

神经科学是一个神经科学.
康复医学康复医学康复医学
神经调节是一种神经调节.

背景情况:

间歇性甲爆刺激 (iTBS) 诱导了快速的皮质促进.
神经肌肉电刺激 (NMES) 激活了感觉运动网络.
同时使用50 Hz的iTBS和NMES显示过渡性皮质脊髓促进.

研究的目的:

研究同步和同步iTBS-NMES对神经调节的剂量-持续时间影响.
为了确定增加刺激持续时间是否增强皮质脊髓促进.

主要方法:

11名身体健康的人接受了四次干预:iTBS-NMES (1,2,3剂量) 和iTBS单独 (3剂量).
干预涉及同步的50Hz iTBS和NMES (2秒开启/8秒关闭).
通过TMS和神经刺激来评估皮质脊髓刺激 (MEP),皮质内抑制 (SICI) 和肌肉疲劳 (Mmax).

主要成果:

显著的运动唤起潜力 (MEP) 促进仅在最高剂量 (iTBS1800-NMES) 后持续至少30分钟.
单独使用iTBS的控制干预措施并没有产生显著的便利性.
短间隔皮质内抑制 (SICI) 和最大运动反应 (Mmax) 没有受到影响.

结论:

增加同步iTBS-NMES的剂量-持续时间延长皮质脊髓促进.
这种效应可能是由于累积激活的结果,超过了恒温值.
重复同步的皮层和外围输入增强了皮层下激活.

关键词:

同时的同时进行.剂量持续时间剂量持续时间间歇性达爆发刺激的时间.神经调节是一种神经调节.神经肌肉电刺激是一种神经肌肉电刺激.

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