相关实验视频

Updated: May 9, 2025

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

在被诊断患有良性前列腺增生症 (BPH) 的老年男性中识别肠道微生物群肠型

Weronika Ratajczak-Zacharko¹, Karolina Skonieczna-Żydecka², Maria Laszczyńska³

¹Department of Functional Diagnostics and Physical Medicine, Faculty of Life Science, Pomeranian Medical University, Szczecin, 71-210, Poland. weronika.ratajczak@pum.edu.pl.

Scientific reports

|May 4, 2025

概括

肠道微生物群的改变与良性前列腺激增症 (BPH) 有关. 特定的肠型,如带有蓝斑,细菌和链球菌的肠型3,在BPH患者中更为普遍,并增加BPH的可能性.

科学领域:

微生物学微生物学
胃肠病学胃肠病学
泌尿器科泌尿器科泌尿器科泌尿器科

背景情况:

人的肠道微生物群在健康和疾病中起着至关重要的作用.
肠道微生物群的组成和功能的障碍与各种病理有关.
新出现的证据表明肠道失调和前列腺疾病之间存在联系,包括良性前列腺增生症 (BPH) 和前列腺癌.

研究的目的:

调查健康男性和BPH患者之间的肠道微生物群组成和肠道类型的差异.
确定特定的微生物模式是否与发展BPH的风险增加有关.

主要方法:

16S rRNA基因测序 (V3-V4区域) 用于分析81名健康对照组和76名BPH患者的便微生物群.
计算了α和β多样性指标,以评估微生物社区结构.
用迪里克莱特多项式建模来识别和比较群体之间的肠型.

主要成果:

在健康个体和BPH患者之间,没有发现α多样性的显著差异.
在两组之间观察到β多样性 (微生物群组成) 的显著差异 (p < 0.001).
肠型分析显示了健康男性和BPH患者之间的显著差异 (p = 0.035). 肠型3,由蓝病,细菌菌和链球菌主导,在BPH患者中最为普遍,与肠型1 (OR = 3.24) 相比,与BPH的可能性增加了三倍.

结论:

肠道微生物组合的变化与良性前列腺增生有关.
特定肠类型的流行,特别是3型肠类型,可能代表与BPH相关的微生物特征.
这些发现凸显了肠道微生物组在BPH病变发生过程中的潜在作用.

关键词:

良性前列腺增生症良性前列腺增生症胃肠道微生物组胃肠道微生物组肠道肠道类型的肠道类型.

更多相关视频

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

相关概念视频

Anatomy of the Intestines

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...

Bacterial Flora of the Large Intestine

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.