相关实验视频

Updated: May 5, 2026

Candida albicans Biofilm Development on Medically-relevant Foreign Bodies in a Mouse Subcutaneous Model Followed by Bioluminescence Imaging

Candida albicans Biofilm Development on Medically-relevant Foreign Bodies in a Mouse Subcutaneous Model Followed by Bioluminescence Imaging

Published on: January 27, 2015

使用病例控制设计在重症监护室创建侵入性角膜炎的预测模型:一种欧洲多中心方法

P M B Benders¹, J Schouten², A Vena³

¹Department of Anesthesiology, Radboudumc, Nijmegen, The Netherlands.

BMC infectious diseases

|May 4, 2025

概括

在重症监护室 (ICU) 患者中预测侵袭性候群病 (IC) 很困难. 使用国际数据的新模型显示,临床使用的预测性能有限.

科学领域:

关键护理医学关键护理医学
传染性疾病传染性疾病
医疗信息学医疗信息学

背景情况:

侵入性候群病 (IC) 在重症监护室 (ICU) 患者的发病率和死亡率显著增加.
目前用于IC的诊断方法缺乏灵敏度,延迟或未经验证用于常规使用.
早期治疗对于改善IC患者的生存率至关重要.

研究的目的:

为了确定使ICU患者易患侵袭性候群病的因素.
使用大型国际数据集开发和验证IC的替代预测模型.

主要方法:

从EUCANDICU数据库中对285个病例和285个匹配的对照进行了追溯分析.
通过单变量分析确定了31个独立的风险因素.
在80%的数据上使用LASSO回归的预测模型的开发,在剩余20%的数据上进行验证.

主要成果:

SAPS II评分,SOFA评分,先前感染,功能障碍和多个Candida定居点独立地与IC风险增加有关.
一个包含22个变量的Lasso回归模型实现了0.7433.3的AUROC.
该模型的预测性能不足以用于临床应用.

结论:

开发一种可靠的预测模型,用于ICU患者的侵入性角膜炎仍然是一个重大挑战.
尽管使用了大型跨国数据库和先进的方法,但当前模型的性能对于临床实践是不够的.
需要进一步的研究,以改善在重症患者中IC的预测.

关键词:

候选血症是什么候选血症是什么候群病是一种候群病.在ICU中,医生会对患者进行治疗.拉索·拉索 (Lasso) 是一个预测模型的预测模型.

更多相关视频

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging

Published on: March 22, 2024

相关概念视频

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

Healthcare Associated Infections II: Preventive Measures

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...