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Updated: May 9, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

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海洋灵感的螺旋二醇 PIM-1 激酶抑制剂同时具有TRKA/CDK2 抑制作用,用于多面非小细胞肺癌的亡诱导

Refaah M Al-Jassas1, Mohammad Shahidul Islam1, Abdullah Mohammed Al-Majid1

  • 1King Saud University College of Science, Chemnistry, SAUDI ARABIA.

ChemMedChem
|May 5, 2025
PubMed
概括

研究人员开发了新的混合分子,同时抑制PIM-1,CDK2和TrkA激酶,用于非小细胞肺癌 (NSCLC) 治疗. 化合物7f显示出显著的细胞毒性和亡诱导,表明作为一种新的NSCLC化疗药物的潜力.

关键词:
在CDK2中使用CDK2.在NSCLCLC中,我们可以看到.这是一种PIM-1激酶.螺旋氧因醇是一种氧醇.这就是TrakA的意思.

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