在轻度认知障碍患者中,吸烟会改变静止状态大脑网络的有效连接性
Tianyi Zhang1, Xiao Luo2, Qingze Zeng2
1Department of Neurology, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Journal of Alzheimer's disease : JAD
|May 5, 2025
概括
吸烟显著改变大脑有效连接 (EC) 在认知正常和轻度认知障碍的个体. 这些变化可能会损害轻度认知障碍的补偿机制,突出强调阿尔茨海默氏症的戒烟.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 公共卫生 公共卫生
背景情况:
- 吸烟是阿尔茨海默病 (AD) 的一个显著可修改的风险因素.
- 吸烟与静态网络 (RSN) 中功能连接受损有关.
- 吸烟导致的有效连接 (EC) 改变需要进一步调查.
研究的目的:
- 研究吸烟对认知正常 (CU) 和轻度认知障碍 (MCI) 个体的有效脑连接 (EC) 的影响.
- 探索吸烟和认知状态对EC的交互影响.
- 为了确定EC是否预测纵向认知衰退.
主要方法:
- 分析了129名CU (85名非吸烟者,44名吸烟者) 和84名MCI (55名非吸烟者,29名吸烟者) 参与者.
- 用格兰杰因果关系分析来评估RSN种子区域之间的定向信息流.
- 混合效应分析检查了吸烟 × 认知状态相互作用和与认知衰退的EC相关性.
主要成果:
- 与其他组相比,吸烟MCI个体的EC从左侧门到前岛皮层 (FIC) 减少.
- 非吸烟的MCI受试者比非吸烟者表现出从背侧前额皮层 (DLPFC) 到右下回 (IOG) 的较低EC.
- 吸烟的CU受试者从DLPFC增加了EC到左中间带状皮层. 特定的EC路径预测了认知衰退.
结论:
- 吸烟对RSN中的EC和CU和MCI个体的整体大脑功能产生重大影响.
- 吸烟可能会降低MCI患者的功能补偿.
- 研究结果支持戒烟作为阿尔茨海默病管理的关键策略.
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