慢性牙炎增加了早期出现阿尔茨海默氏症的风险
Dongcan Mo1, Xiaoling Li1, Jing He2
1Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Journal of Alzheimer's disease : JAD
|May 5, 2025
概括
慢性牙周炎可能会增加早期阿尔茨海默病 (AD) 的风险. 这项研究使用门德尔的随机化和生物信息学来探索这种联系,并确定AD的潜在诊断生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 口腔健康 口腔健康
背景情况:
- 牙周病,包括牙周炎和牙周炎,与阿尔茨海默病 (AD) 有关,但因果关系仍然未被证明.
- 现有的证据不足以确定牙周病和AD之间的因果关系.
- 调查这种联系对于理解AD病原体和制定预防策略至关重要.
研究的目的:
- 使用孟德尔随机化 (MR) 调查牙炎,牙周炎和阿尔茨海默病 (AD) 之间的因果关系.
- 通过基于转录组的生物信息学来识别早期发病的AD (EOAD) 的潜在诊断生物标志物.
- 探索连接牙周病和阿尔茨海默病的潜在病原体.
主要方法:
- 孟德尔随机化 (MR) 分析使用逆方差加权 (IVW) 和MR-Egger方法与开放GWAS数据.
- 对基因表达综合 (GEO) 数据集的生物信息学分析,包括转录组测序,基因本体学和基因和基因组 (KEGG) 京都百科全书的途径分析.
- 使用蛋白质-蛋白质相互作用网络和LASSO回归来构建和验证EOAD的诊断特征.
主要成果:
- 门德尔随机分析表明慢性牙炎与EOAD风险增加之间存在显著的正相关性 (IVW:OR=1.161,p=0.035;MR-Egger:OR=1.296,p=0.049).
- 反向因果关系没有得到分析的支持.
- 关键途径涉及免疫激活,血管生成和血脑屏障损伤;确定了Inter-alpha-trypsin抑制剂重链H5 (ITIH5) 基因和TGFB途径.
- 一个三基因签名 (ITIH5,MFAP4,PRELP) 表明了EOAD诊断的潜力.
结论:
- 慢性牙炎与患早期阿尔茨海默病 (EOAD) 的风险增加有关.
- 免疫反应,血管生成和受损的血脑屏障功能可能会调解牙周炎和EOAD之间的联系.
- 鉴定的基因特征对EOAD的早期诊断具有前途.
更多相关视频
09:33Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
Published on: December 26, 2016
7.9K
09:45Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
Published on: March 22, 2016
10.1K
相关概念视频
Alzheimer's Disease: Overview
315
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
315
Psychoneuroimmunology: Diabetes and Cancer
16
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
16
Dementia
64
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
64
Alzheimer's Disease: Treatment
128
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
128
