双醇对辅助生殖技术产生的影响 考虑到患者的临床参数
Marie-Emilie Lebachelier de la Riviere1, Marie Bousquet1, Elsa Tavernier2
1INRAE, CNRS, Université de Tours, PRC, Nouzilly 37380, France.
Journal of the Endocrine Society
|May 5, 2025
概括
双暴露会影响生育能力,肥胖可能会降低活产率. 年轻的女性更年轻的女性.
科学领域:
- 内分泌学 在内分泌学.
- 生殖生物学 生殖生物学
- 环境健康 环境健康
背景情况:
- 双 (BP) 化合物,包括双A (BPA),破坏内分泌功能.
- 暴露于BP会对卵细胞质量,成熟和花质细胞 (GC) 类固醇生成产生不利影响.
研究的目的:
- 调查临床因素,特别是脂肪和年龄,影响卵巢细胞对血压暴露的敏感性.
- 评估BP暴露对辅助生殖技术 (ART) 结果的影响.
主要方法:
- 从368名接受ART的妇女的卵泡液中量化了四个BP (BPA,BPS,BPF,BPAF).
- 使用回归模型评估ART结果 (卵细胞计数,胚胎质量,怀孕率).
- 从156名患者培养了GC,将其暴露在BPS中,并测量了类固醇分泌.
主要成果:
- 双S (BPS) 和BPA在卵泡液中普遍存在;BP暴露与受精率降低相关 (P = .05).
- 肥胖与较低的活产率有关 (P = .08),但没有影响胚胎发育.
- 晚年母亲的年龄显著影响了胚胎数量 (P < .001) 和质量 (P = .03).
- 在BPS暴露后,GC孕分泌与供体年龄相关 (P = .03);年轻女性的GC显示出更高的BPS敏感性.
结论:
- 虽然肥胖没有影响胚胎发育,但它与降低活产率有关.
- 母亲年龄对ART结果产生了重大影响,包括怀孕和活产率.
- 来自年轻女性的粒状细胞可能对BPS更敏感,这表明对内分泌干扰物的反应可能存在与年龄相关的差异.
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