儿科垂体腺瘤和囊:46年的基于人口的分析
Kaitlin Leopold1, Mostafa Salama1, Seema Kumar1
1Division of Pediatric Endocrinology and Metabolism, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Journal of the Endocrine Society
|May 5, 2025
概括
儿科垂体腺瘤和囊是罕见的,大多数是小的和非功能性的. 这些病变通常随着时间的推移而稳定,需要进一步研究长期管理策略.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 神经瘤学神经瘤学
- 流行病学 流行病学
背景情况:
- 下垂体腺瘤和囊在儿童中不常见,需要更好地了解有效的管理.
- 对儿科垂体病变的更好了解可以为临床实践指南提供信息.
研究的目的:
- 确定儿童群体中垂体腺瘤和囊的发病率,临床表现,管理和结果.
- 调查病变特征 (大小,头痛) 与疾病进展,以及MRI率之间的相关性.
主要方法:
- 在小儿病患者 (≤18岁) 的回顾性队列研究,在奥姆斯特德县的垂体腺瘤/囊,MN (1976-2021).
- 利用罗切斯特流行病学项目的诊断代码,从234名独特的患者中识别出37例确诊病例.
- 使用描述性统计数据计算发病率和分析临床数据.
主要成果:
- 发生率为每10万人/年2.29例.
- 最常见的类型是非功能性 (68%) 和前乳腺瘤 (27%);GH和TSH分泌腺瘤是罕见的.
- 病变的中位数大小为5.5毫米;中位数随访时间为7.4年. 疾病进展发生在4名患者中,随着治疗稳定. 在MRI率,病变大小或头痛和疾病进展之间没有发现显著的相关性.
结论:
- 儿科垂体腺瘤和囊是罕见的,通常是小的,非功能性的,并在长期随访期间表现出稳定性.
- 需要进一步的大规模研究来阐明小,非功能性垂体病变的自然史,并完善管理建议.
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