神经认知障碍中的精神病在种族文化多样化的老年人中
Estevana Isaac1, Carolyn Wei Zhu2, Monica Rivera Mindt3,1
1Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY.
Neurology. Clinical practice
|May 5, 2025
概括
种族和少数民族,包括黑人非拉丁裔,拉丁裔和美洲印第安人/阿拉斯加土著人,在神经认知障碍 (NCD) 中面临更高的精神病率. 这些差异甚至存在于认知障碍早期阶段.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 神经认知障碍 (NCD) 中的精神病与加速的认知和功能衰退有关.
- 了解非传染性疾病中精神病的种族差异至关重要,即使是在早期阶段.
研究的目的:
- 研究患有非传染性疾病的种族群体中临床医生诊断的精神病的差异.
- 为了检查这些差异是否存在于没有晚期痴呆症的个体中.
主要方法:
- 国家阿尔茨海默氏症协调中心统一数据集 (22,854名参与者) 的回顾性分析.
- 纳入标准:轻度认知障碍 (MCI) 或痴呆症 (40-95岁).
- 精神病被定义为临床医生诊断的幻觉或妄想;使用多变量逻辑回归分析,控制共变量.
主要成果:
- 美国印第安人/阿拉斯加原住民 (AI/AN),黑人拉丁裔,其他拉丁裔,黑人非拉丁裔 (NL) 和白人拉丁裔参与者与白人NL参与者相比,在非传染性疾病中精神病的几率更高.
- 在较年轻的年龄组 (<65岁),只有黑人NL参与者患精神病的几率更高.
- 在较轻的痴呆阶段,AI/AN,黑人拉丁裔,其他拉丁裔,黑人NL和白人拉丁裔参与者患精神病的几率显著增加.
结论:
- 与白人NL人相比,黑人NL,拉丁裔和AI/AN人群在非传染性疾病中表现出更高的精神病率.
- 在单独患有MCI的参与者中,没有观察到精神病的显著差异.
- 对社会文化,心理社会和神经病理因素的进一步研究是有必要的,以解释这些差异.
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