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在重大抑郁症中,描绘皮质形态与功能网络之间的合

Peng Wang¹, Li Lu¹, Jinghua Wang¹

¹Center for Cognition and Brain Disorders/Department of Neurology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China.

Depression and anxiety

|May 5, 2025

概括

大型抑郁症 (MDD) 显示大脑形态功能合 (MFC) 发生变化. 像视觉网络这样的特定网络表现出增加的MFC,与症状严重程度相关,为MDD提供了洞察力.

科学领域:

神经科学是一个神经科学.
脑部成像脑部成像
精神病学是一个精神病学.

背景情况:

了解大脑结构和功能之间的关系对于破译精神障碍至关重要.
大型抑郁症 (MDD) 的特点是大脑网络的复杂变化.
皮质形态功能合 (MFC) 是大脑组织的一个关键方面.

研究的目的:

为了研究皮质形态-功能合 (MFC) 在患有重大抑郁症 (MDD) 的人与健康对照人相比如何不同.
探索改变的MFC模式和MDD的临床症状之间的关系.
阐明MFC在MDD神经生物学中的作用.

主要方法:

利用了830名MDD患者和853名健康对照 (HC) 的高分辨率T1加权结构MRI和静止状态功能MRI (rs-fMRI) 数据.
基于皮质灰质 (GM) 形态和rs-fMRI时间序列相关性构建了单独的形态和功能性大脑网络.
通过评估形态和功能网络之间的空间一致性来量化MFC.

主要成果:

患有MDD的患者表现出类似的MFC和HC等级模式,但具有显著的网络特异性变化.
在视觉网络 (VIS) 和感觉运动网络 (SMN) 中观察到较低的MFC,而在默认模式网络 (DMN) 和前端对象网络 (FPN) 中发现较高的MFC.
与HC相比,MDD患者在VIS,感觉运动网络 (SMN) 和背部注意网络 (DAN) 中显著增加了MFC. 在VIS中改变的MFC与抑郁症状严重程度正相关.

结论:

在主要抑郁症 (MDD) 中,皮层形态功能合 (MFC) 发生变化,特别是在特定的功能性大脑网络中.
视觉网络 (VIS) 中MFC的增加与MDD中抑郁症状严重程度的增加有关.
这些发现突显了MFC作为神经成像生物标志物的潜力,用于理解和潜在地治疗MDD.

关键词:

连接器连接器的连接器功能性网络是一种功能性网络.大型抑郁症主要是抑郁症.形态上的相似性.结构性网络结构性网络

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