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在主观认知衰退中较低的气味识别:一个元分析
Benoît Jobin1,2,3, Coline Zigrand4,5, Johannes Frasnelli2,6,5
1Department of Psychology, Université du Québec à Trois-Rivières, 3351 Boulevard des Forges, Trois-Rivières, QC G9A 5H7, Canada.
概括
在主观认知衰退 (SCD) 患者中,嗅觉识别能力较低,这表明嗅觉缺陷可能在认知障碍之前出现. 这一发现支持使用气味识别测试用于早期阿尔茨海默病 (AD) 查.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 嗅觉研究 嗅觉研究
背景情况:
- 嗅觉识别的下降与阿尔茨海默病 (AD) 生物标志物有关.
- 嗅觉缺陷可能会在可测量的认知衰退之前出现,甚至在主观认知衰退 (SCD) 阶段出现.
研究的目的:
- 为了比较SCD和认知正常 (CN) 个体之间的气味识别能力.
- 调查认知差异是否影响这些群体的嗅觉缺陷.
主要方法:
- 在四个数据库中进行了系统的文献搜索.
- 随机效应的元分析综合了来自11项研究的数据,其中包括660名SCD和574名50岁以上的CN参与者.
主要成果:
- 与CN参与者相比,SCD患者的气味识别得分明显较低 (SMD = -0.67,p = .04).
- 超回归表明,SCD中的嗅觉缺陷发生在显著的认知差异之外,没有更大的认知衰退和更大的嗅觉障碍之间的一致关联.
结论:
- 在SCD患者中观察到减少嗅觉识别,这表明嗅觉衰退可能在明显的认知障碍之前出现.
- 气味识别可以作为一种有价值的,非侵入性查工具,用于早期检测阿尔茨海默病风险.
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