从临床抽血中未使用的样本作为最大化研究样本的资源,同时减轻阳性贫血风险:试点研究
Ian S Jaffe1, Imad Aljabban1,2, Jacqueline I Kim1
1Department of Surgery, New York University Grossman School of Medicine, 317 East 34th Street, New York, NY, USA 10016.
概括
研究人员可以回收未使用的临床血液样本用于研究,显著增加血产量. 这种方法可以节省患者的血量,并支持翻译研究工作.
科学领域:
- 生物医学研究生物医学研究
- 临床病理学 临床病理学
- 翻译科学 翻译科学
背景情况:
- 大规模的翻译研究需要大量的血液.
- 临床血液抽取患者管理必须优先考虑.
- 临床抽取血液的很大一部分仍未使用.
研究的目的:
- 提出一种用于检索和回收未使用的临床血液样本用于研究的方法.
- 评估从临床废物中增加研究血液样本数量的可行性.
主要方法:
- 在60天内从临床实验室收集未使用的血液样本 (血,血清,红细胞,PBMC).
- 采集了超过12小时的样本,对其进行了非识别,并在中央生物存储库中进行了处理.
- 从回收的临床样本中比较样本产量与专门的研究绘制.
主要成果:
- 回收的临床样本每天至少产生6.0毫升血 (62%的总血).
- 血清恢复是有限的 (8%的总血清) 和不一致.
- 周围血液单核细胞 (PBMC) 的恢复也很少 (10%的天).
结论:
- 过度抽取的临床血液样本是研究的宝贵,尚未开发的资源.
- 回收临床样本可以增加研究血液体积,并最大限度地减少催产素引起的血液损失.
- 战略规划可以有效地利用临床血液浪费用于研究.
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