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相关概念视频

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
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加速度计测量身体活动和神经成像驱动的大脑年龄.

Han Chen1, Zhi Cao1,2, Jing Zhang1

  • 1School of Public Health, Hangzhou Normal University, Hangzhou, China.

Health data science
|May 5, 2025
PubMed
概括

参与适度的体力活动 (PA) 与更健康的大脑衰老有关,通过大脑年龄差距 (BAG) 来衡量. 太少和太多的PA都会对大脑健康产生负面影响,这表明U形的关联.

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科学领域:

  • 神经成像是一种神经成像.
  • 生物标志物 生物标志物
  • 衰老研究研究 衰老研究

背景情况:

  • 大脑年龄,一个神经成像生物标志物,反映了大脑衰老和整体大脑健康.
  • 身体活动 (PA) 强度对大脑年龄的影响尚未完全理解.
  • 这项研究调查了加速器测量PA和大脑年龄之间的联系.

研究的目的:

  • 检查不同强度的体力活动 (PA) 与大脑年龄差距 (BAG) 之间的关联.
  • 为了确定PA水平是否会影响大脑衰老的速度.
  • 探索BAG在PA和健康结果之间的关系中的调解作用.

主要方法:

  • 利用了来自16972名参与者的英国生物库数据,以及神经成像和加速度计数据.
  • 使用光梯度增强机器 (LightGBM) 估计的大脑年龄,从1400多个图像衍生表型 (IDP) 中进行特征选择.
  • 分析了轻度,中度,强度和中度至强度PA和BAG之间的非线性关联,使用了通用添加模型.

主要成果:

  • 大脑年龄预测模型表现良好 (r=0.81,MAE=3.65),随着偏差校正得到改善 (r=0.90,MAE=3.03).
  • 所有的PA强度 (LPA,MPA,VPA,MVPA) 都与BAG呈U形关系,表明缺乏和过度活动的不良影响.
  • 发现大脑年龄差距 (BAG) 部分调解了PA和认知功能/大脑障碍之间的关系.

结论:

  • 在客观测量身体活动和大脑年龄差距之间存在U形的关联.
  • 最佳的大脑健康与适度的体力活动有关,无论强度如何.
  • 研究结果表明,身体活动会影响大脑衰老以及通过大脑年龄的相关健康结果.