在老年2型糖尿病患者中血清胆汁酸的概况 患有各种肥胖类型的糖尿病患者:一个横截面研究
Mengxiao Guo1,2, Yuejian Mao3, Feng Xie4
1Shanghai Innovation Center of Traditional Chinese Medicine Health Service, School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
概括
在2型糖尿病 (T2DM) 肥胖现象中,胆酸概况不同. 像GDCA,TDCA和LCA这样的特定胆汁酸 (BA) 与脂肪性有关,可能是管理肥胖患者T2DM的关键标.
科学领域:
- 代谢学 代谢学 代谢学
- 内分泌学 在内分泌学.
- 糖尿病研究 糖尿病研究
背景情况:
- 身体脂肪分布显著影响2型糖尿病 (T2DM) 的发病.
- 区分T2DM肥胖现象型的明显的代谢特征需要进一步阐明.
- 胆酸 (BAs) 是葡萄糖和脂质代谢中的关键信号分子.
研究的目的:
- 调查和比较T2DM患者不同肥胖表型的胆酸 (BA) 概况.
- 为了确定与T2DM中不同肥胖亚型相关的特定BA.
- 了解BA在管理不同肥胖模式的T2DM中的临床意义.
主要方法:
- 涉及99名来自上海的老年参与者的横截面研究.
- 分类为四组:非糖尿病对照 (NC),T2DM瘦 (TN),T2DM超重 (TO) 和T2DM腹部肥胖 (TA).
- 生物化学指数,内脏脂肪指数和综合胆酸 (BA) 概况的分析.
主要成果:
- 健康的个体比T2DM患者显示出较低的甘油三,WHR,VAI,CVAI,以及较高的HDL-c和总BA.
- 在T2DM肥胖现型中观察到明显的BA概况:TN组具有更高的合DCA,GDCA,TDCA;TA组具有更高的12α-氧化BA比率,12α-氧化BA比率, taurine/glycine BA比率和LCA.
- CVAI与未结合的SBA,CA-7S和DLCA正相关.
结论:
- 患有不同肥胖现象型的T2DM患者表现出独特的胆酸 (BA) 形状.
- 特定的BA (GDCA,TDCA,LCA) 与脂肪指数密切相关,可能调节内脏脂肪,脂质和葡萄糖平衡.
- 这些BA在糖尿病和肥胖病原发生过程中起着关键作用,为T2DM亚型提供治疗点的潜力.
相关概念视频
01:24Obesity
300
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
300
01:29Cholesterol: Significance and Regulation
457
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
457
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
99
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
99
01:36Carbohydrate Metabolism
10.5K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.5K
01:15Diabetes: Symptoms, Diagnosis, and Complications
471
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
471
01:24Overview of Lipid Metabolism
789
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
789