母亲免疫介导疾病和子女多动症多动症风险
Kjersti Maehlum Walle1, Kristin Gustavson2, Siri Mjaaland1
1Norwegian Institute of Public Health.
Research square
|May 5, 2025
概括
怀孕期间母亲的免疫状况会增加后代的ADHD风险,这表明非遗传因素. 父亲的喘也与儿童患ADHD的风险更高有关.
科学领域:
- 生殖免疫学 生殖免疫学
- 发育神经科学的发展神经科学.
- 儿科卫生保健 儿科卫生保健
背景情况:
- 母亲的免疫介导疾病与后代的ADHD风险有关.
- 共享遗传与母亲免疫反应的作用尚不清楚.
- 这项研究使用父亲的条件作为负控制来区分这些因素.
研究的目的:
- 调查怀孕期间母亲免疫介导疾病与后代ADHD风险之间的关联.
- 为了区分母亲免疫反应的影响与遗传倾向.
- 探索影响胎儿发育的潜在机制.
主要方法:
- 利用了挪威母亲,父亲和儿童队列研究 (MoBa) 的前性数据,与国家卫生登记处联系在一起.
- 评估了母体免疫状况 (过敏,自身免疫,炎症) 与子女多动症 (ADHD) 到18岁之间的关联.
- 采用了考克斯的比例危险模型,使用父亲的免疫状况作为基因混杂的负控制.
主要成果:
- 母亲的过敏状况 (HR 1.23) 和其他免疫状况 (HR 1.36) 与后代的ADHD风险增加有关.
- 特定的母亲疾病,如喘 (HR 1.47),过敏 (HR 1.20) 和1型糖尿病 (HR 2.50) 显示出显著的关联.
- 父亲喘 (HR 1.26) 也与后代的ADHD风险有显著联系,与大多数其他父亲疾病不同.
结论:
- 孕产妇的免疫介导疾病与ADHD风险增加有关,这表明它对胎儿发育有直接影响.
- 研究结果表明,未测量的遗传混并不能完全解释这些关联.
- 喘可能涉及母亲的免疫路径和共同的遗传因素,有助于后代的ADHD风险.
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