在COVID-19疫苗接种后出现的新发性血液疾病:系统性审查
Nelson Luis Cahuapaza-Gutierrez1,2, Cielo Cinthya Calderon-Hernandez1,2, Renzo Pajuelo-Vasquez1,2
1Universidad Científica del Sur, Lima, Perú.
Clinical and experimental vaccine research
|May 5, 2025
概括
接种COVID-19疫苗后可能会导致血液学疾病,特别是免疫性血栓塞缩性紫外线,在第一剂mRNA疫苗后. 成年人,特别是女性,需要密切监测这些罕见但严重的不良事件.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 冠状病毒疾病2019 (COVID-19) 疫苗接种在全球范围内显著降低了严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染率.
- 尽管有好处,但疫苗接种后有各种并发症,包括血液学障碍,有事报道.
研究的目的:
- 系统地审查和分析有关COVID-19疫苗接种后血液学疾病发生率和特征的现有证据.
- 为了确定特定的疫苗类型,患者人口统计和与这些不良事件相关的时间模式.
主要方法:
- 对已发表的文献进行了系统的审查.
- 综合和分析了227名报告COVID-19疫苗接种后血液学疾病的患者的数据.
- 评估了患病率,疾病类型,疫苗类型和患者结果.
主要成果:
- 免疫性血栓缩紫外线 (25.55%) 和血栓性血栓缩紫外线 (16.74%) 是最常见的血液学疾病.
- 基于信使RNA (mRNA) 的疫苗 (Pfizer-BioNTech,Moderna) 是最常见的 (66.08%),大多数病例发生在第一剂后 (52.86%).
- 在77.09%的患者中观察到有利的结局,但死亡率发生在10.13%.
结论:
- 接受首剂mRNA COVID-19疫苗的成年人患血液病的风险更高.
- 建议在初始mRNA疫苗剂量后对患者,特别是成年人进行密切监测.
- 需要进一步研究疫苗引起的血液疾病的机制和危险因素.
相关概念视频
Vaccinations
43.0K
Overview
43.0K
Regulation of Hematopoietic Stem Cells
3.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.1K
Disorders of Leukocytes
707
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
707
Disorders of Hemostasis
638
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
638


